Research Project

OptiKnee

A software-based expert system for precise knee arthroplasty.

Patient-specific knee implants offer better long-term treatment outcomes, but often fail to reach clinical practice because of the high costs of design and manufacturing. OptiKnee is developing a software-based expert system that significantly reduces the manual effort involved in designing and manufacturing individualized cutting and drilling guides for knee implants – for more precise, faster, and more cost-effective patient care.

OptiKnee – Preoperative planning of the knee joint: CT slice with axis measurement and a color-segmented 3D model of the femur and tibia
AI-assisted surgical guide design for knee implants A BMBF-funded project within the AGENT-3D network Duration: 10/2020 – 12/2021 © Photo: Dornheim Medical Images

in collaboration with clinical and scientific partners

Planning and positioning patient-specific knee implants with precision

Compared with standard implants, patient-specific knee implants offer better long-term care, yet they often fail to reach clinical practice because of the high costs of design and manufacturing. OptiKnee addresses precisely this problem: through automation and computer-assisted methods, it significantly reduces the time-consuming and costly manual effort involved in designing and manufacturing individualized cutting and drilling guides for knee implants.

The key lies in the precise segmentation of bone structures from CT data and the automatic generation of custom-fit surgical guides. These take into account not only the patient's individual anatomy but also the specific features of the selected implant – enabling optimal positioning and a minimally invasive surgical technique.

The focus lies on developing a software-based expert system that supports surgeons in preoperative planning while at the same time reducing manufacturing costs. In this way, individualized medical technology becomes accessible for routine clinical use.

Challenges and solution approaches

One of the greatest challenges in the project was the precise segmentation of the bone contact surfaces within the joint region. This is where the femur and tibia meet, often with only minimal intensity differences in the CT data, which makes automatic delineation difficult. Added to this are cartilage structures and pathological changes such as osteophytes, which are barely visible on standard CT scans.

The OptiKnee team developed an innovative two-stage segmentation workflow: first, an idealized 3D model is generated for the outer implant dimensions, then a precise surface model for positioning the surgical guides. By combining several segmentation techniques (interactive region growing, morphological operations, and thresholding methods), the team created a robust process that delivers reliable results even with challenging image data.

A particularly successful approach was the deliberate reduction of the guides' contact surface: by focusing on the areas critical to positioning, uncertain segmentations are avoided while material and manufacturing costs are saved at the same time. This makes the surgical procedure more precise and less invasive.

The OptiKnee planning tool

At the heart of the project is a prototype surgical planning tool that guides surgeons through the entire planning process. In the form of an interactive checklist, all relevant measurements and planning steps are worked through in the optimal sequence – from determining the axis and positioning the cutting surfaces to selecting the implant.

The tool offers a range of visualization options (2D and 3D), real-time measurements, and correction functions. Especially innovative is its dynamic adaptation to individual surgeon preferences: since every surgeon has different preferences for cutting-surface positions, the system allows flexible adjustments while at the same time providing default settings as a starting point.

A web-based version is planned for the future, enabling interdisciplinary collaboration among radiologists, surgeons, and manufacturing experts. Planning data can thus be transferred seamlessly from the operating room to additive manufacturing.

Contributions by Dornheim Medical Images

In the OptiKnee project, Dornheim Medical Images made significant contributions to image processing, 3D reconstruction, and interactive planning. The methods developed for the automated segmentation of bone structures from CT data enable, for the first time, the precise generation of the contact surfaces critical to positioning the surgical guides. Particularly innovative is the two-stage segmentation workflow, which combines an idealized model for the implant dimensions with a precise surface model for positioning the guides.

In addition, a prototype surgical planning tool was developed that guides surgeons through the entire planning process while allowing individual adjustments. The results feed directly into the ongoing development of the Dornheim Segmenter and are being made available as specialized modules for orthopedic planning.

Insights into the project

Automated 3D segmentation of the femur at the knee joint from CT data in the Dornheim Segmenter
Automated 3D segmentation of the knee bones from CT data in the Dornheim Segmenter.
3D surface model of the femur reconstructed from the CT data
Reconstructed 3D surface model of the bone as the basis for the surgical guide design.
Prototype positioning of a knee implant on the 3D bone model
Prototype positioning of the implant and cutting planes during surgical planning.

Scientific publications

Smart surgical template models for customized knee joint replacements. Sembdner, P.; Bust, B.; Dornheim, L.; Holtzhausen, S.; Stelzer, R. In: Current Directions in Biomedical Engineering. Vol. 7, No. 2, pp. 129-132, 2021. ResearchGate

What the project produced

The methods and workflows for automated 3D segmentation and surgical guide planning developed in the OptiKnee project form the basis for a software-based expert system that considerably simplifies the design process for patient-specific knee implants. The results are being integrated step by step into the Dornheim Segmenter as specialized modules, making them available for clinical practice.

Federal Ministry of Education and Research (BMBF)

Federal Ministry of Education and Research (BMBF)

The research project “OptiKnee – Design and additive manufacturing of surface- and structure-optimized knee implants and their associated surgical guides” was funded by the BMBF within the “Zwanzig20 – Partnership for Innovation” program (funding reference: 03ZZ0235A). The project was part of the AGENT-3D network for additive manufacturing in medical technology.